Covid related articles from Medscape

Discussion in 'The VIP Lounj' started by pillatier, May 4, 2020.

  1. pillatier

    pillatier Bronze Member

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  2. pillatier

    pillatier Bronze Member

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    Arizona Health Dept is alerting hospitals to get ready to handle increased numbers of new cases.
     

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  3. pillatier

    pillatier Bronze Member

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    Covid -19 vaccines in development - article covers the one in Phase 1 and 2 clinical trials.
     

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  4. pillatier

    pillatier Bronze Member

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    Recently we learned from a small clinical trial that Dexamethsone may help in reducing inflammation and ventilator use. It makes sense theoretically at least. Now there is another - Low Dose Radiation. See attached.

    Corona virus parties - a bad (stupid IMO) idea - see attached.
     

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  5. Carl V

    Carl V Bronze Member Donor Top Poster

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    Dex. Is ok for advanced situations. The caveat is diminished auto immune responses to as my other issue. We're still searching.
     
  6. Denton

    Denton Bronze Member Donor Top Poster

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  7. pillatier

    pillatier Bronze Member

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    Antibodies may not last.
    Herd immunity - not so fast from Sweden study
    FEMA got soda bottles not test tubes. On a related matter I am curious how much money the States were forced to overspend/waste in competing for PPEs. I wish there was a study.
     

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  8. pillatier

    pillatier Bronze Member

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    GA hospital does retests to fake -ve results. I say this is criminal.
     

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    Last edited: Jun 23, 2020
  9. pillatier

    pillatier Bronze Member

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    COVID-Sorting': How We Decide Whom to Get Close to and Whom to Avoid
     

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  10. pillatier

    pillatier Bronze Member

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    Based on the attached only those who got seriously ill enough to be hospitalized developed the type and quantity of antibody that MAY prevent re-infection. IOW a +ve antibody test does not mean immunity.
     

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  11. pillatier

    pillatier Bronze Member

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    Two more
    Three stages of brain damage
    Altered mental state and psychosis onset
     

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  12. pillatier

    pillatier Bronze Member

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    Two more -
     

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  13. pillatier

    pillatier Bronze Member

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    Proton pump inhibitors, (e.g. Pepcid, Zantac, Nexium, Prilosec etc) use doubles Covid infection rate -

    Covid19 vaccine may cost us dearly
     

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  14. pillatier

    pillatier Bronze Member

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    Problem with too many treatment trials -
    "Positive trials get way more airtime than negative or neutral ones, and that shapes the public perception of drug efficacy. And, honestly, it shapes physicians' perceptions too.:

    "There's another problem with all these trials of the same thing: There aren't enough patients. Of the 201 trials recruiting solely in the US, the total expected enrollment was 146,688 individuals; 87,000 patients
    are needed to be enrolled in chloroquine-specific trials alone. It is not easy to recruit patients into clinical trials. This many, even with a raging pandemic, is not feasible. Many of these studies will never finish.
    So, what are we to do? Well, the number-one thing is to realize that there will be individual randomized trials of interventions that don't actually work but are nevertheless positive. This will happen. You will see
    on the news that a new randomized trial shows that chloroquine or some other drug reduces mortality in COVID-19, and you will not be told of all the other trials that show that it doesn't.
    First, we need to be
    aware of this.."
     

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  15. pillatier

    pillatier Bronze Member

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    Perhaps a little good news - ICU death rates dropped from 60 to 40%
     

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  16. pillatier

    pillatier Bronze Member

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    Misinformation about ibuprofen use. Yes it can be used. My note - ibuprofen is better for inflammation, acetaminophen is better for fever. Acetaminophen with alcohol NO NO.

    Drug treatments for Covid - Only two useful drugs Remdesivir and Dexamethasone.

    Antibodies after infection does not last long. Acquiring herd immunity may not be attainable.

    Long Covid - Many symptoms last long after.
     

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  17. pillatier

    pillatier Bronze Member

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    Diabetes Type 1 and 2, hypertension
    "Further refinement of data from patients hospitalized worldwide for COVID-19 disease showed a 12% prevalence rate of patients with diabetes in this population and a 17% prevalence rate for hypertension."

    Heart damage even after recovery specter of future heart failure
     

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  18. pillatier

    pillatier Bronze Member

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    Role of kids and school in spreading Covid 19 -
    ""Our analyses suggest children younger than 5 years with mild to moderate COVID-19 have high amounts of SARS-CoV-2 viral RNA in their nasopharynx compared with older children and adults," report Taylor
    Heald-Sargent, MD, PhD, and colleagues. "Thus, young children can potentially be important drivers of SARS-CoV-2 spread in the general population, as has been demonstrated with respiratory syncytial virus,
    where children with high viral loads are more likely to transmit."
    Although the study "was not designed to prove that younger children spread COVID-19 as much as adults," it is a possibility, Heald-Sargent said in a related news release....."

    Accuracy of 10 minute Covid test -
    "FebriDx was performed on 251 patients and gave a valid result in 248. A total of 118 of 248 (48%) were PCR positive for COVID-19....." . The article concluded good enough to triage potential patients but not good enough for definitive +ve or -ve decision.

    Staggering increase in depression -
    "The new data, released by Mental Health America (MHA), came from individuals who completed a voluntary online mental health screen.

    As of the end of June, over 169,000 additional participants reported having moderate to severe depression or anxiety compared with participants who completed the screen prior to the pandemic.

    In June alone, 18,000 additional participants were found to be at risk for psychosis, continuing a rising pattern that began in May, when 16,000 reported psychosis risk.

    "We continue to see staggering numbers that indicate increased rates in depression and anxiety because of COVID-19," Paul Gionfriddo, president and CEO of MHA, said in a release....."

    Pilot study - Trained dogs may detect Covid patients
    "Eight dogs, which are part of the German Armed Forces, were trained for a week to detect the virus in samples of saliva. Then they were given more than 1,000 infected and non-infected samples and were able
    to detect 94% of cases. They correctly identified 157 positive samples and 792 negative samples but missed 30 positive samples and gave false positives for 33 samples....."
     

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  19. pillatier

    pillatier Bronze Member

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  20. pillatier

    pillatier Bronze Member

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    Is Gilead sitting on another compound because it has a shorter patent life?
    Is Gilead sitting on a potentially more effective, albeit less lucrative, Covid-19 drug?
    Yes, according to a pair of researchers at MD Anderson and the advocacy group Public Citizen. The groups are out with a new open letter attempting to pressure Gilead into studying another compound in the company’s portfolio, GS-441524, that they believe might be effective in treating coronavirus — and potentially more effective and easier to manufacture than the company’s approved product, remdesivir.

    The authors claim that lab tests show the compound, is “similar or superior" to remdesivir and more easily synthesized. They also imply that that the company is uninterested in commercializing the drug because it has a shorter patent life than remdesivir.

    “It is unclear why Gilead and federal scientists have not been pursuing GS-441524 as aggressively as remdesivir, but we cannot help but note that there are significant financial incentives tied to Gilead’s current patent holdings,” the letter states. “Gilead’s monopoly power over remdesivir may have at least five additional years of enforceability beyond that of GS-441524.”

    IMO if this compound works and Gilead was sitting on it because of patent life then the company should be required to disgorge all profits from Remdesivir.
     

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